Oxygen → HCID 178420775, compound

HRID 889852Notes

Reaction equation

HRID 889852 reaction equation
C(C1C2(C)OC(=O)C(SCC[N:23]3[CH:27]=[N:26][C:25]([C:28]4[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=4)=[N:24]3)C2C(C)C(=O)C(C)CC(OC)(C)C(O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)C(C)C(=O)C(F)(C)C(=O)O1)C.O=O.OCCN1C=NC(C2C=NC=CC=2)=N1>>[N:30]1[CH:31]=[CH:32][CH:33]=[C:28]([C:25]2[N:26]=[CH:27][NH:23][N:24]=2)[CH:29]=1

Participants

4

Reactant 3

HCID 977OxygenHCID 22247836HCID 22247836, compoundHCID 86759926HCID 86759926, compound

Product 1

HCID 178420775HCID 178420775, compound

Procedure

Preparation of (3R or S, 3aR, 4R or S, 6R, 8R, 9R, 10R, 12S, 15R, 15aS)-15-Ethyl-12-fluorooctahydro-8-methoxy-4,6,8,10,12,15a-hexamethyl-3-[[2-[3-(3-pyridinyl)-1H-1,2,4-triazole-1-yl]ethyl]thio]-9-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-furo [2,3-c] oxacyclotetradecin-2,5,11,13 (3H,6H,12H)-tetrone (I-12), compound of formula I where R1 is [2-[3-(3-pyridinyl)-1H-1,2,4-triazol-1-yl]ethyl]thio, R2 is fluoro, R3 is methyl and Z is oxygen. A] 3-(3-Pyridinyl)-1,2,4-triazole was prepared according to Lin et al. J. Org. Chem. 1979, 44, 4160. B] 1-(2-Hydroxyethyl)-3-(3-pyridinyl)-1H-1,2,4-triazole

Sources & evidence

ORD record
ord-6ab951df64a5421a91b3851533bbd243
Source dataset
uspto-grants-2006_02
Patent number
US06995143B2

Reaction notes

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