Oxygen → HCID 178420775, compound

Participants

Reaction Steps

Preparation of (3R or S, 3aR, 4R or S, 6R, 8R, 9R, 10R, 12S, 15R, 15aS)-15-Ethyl-12-fluorooctahydro-8-methoxy-4,6,8,10,12,15a-hexamethyl-3-[[2-[3-(3-pyridinyl)-1H-1,2,4-triazole-1-yl]ethyl]thio]-9-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-furo [2,3-c] oxacyclotetradecin-2,5,11,13 (3H,6H,12H)-tetrone (I-12), compound of formula I where R1 is [2-[3-(3-pyridinyl)-1H-1,2,4-triazol-1-yl]ethyl]thio, R2 is fluoro, R3 is methyl and Z is oxygen. A] 3-(3-Pyridinyl)-1,2,4-triazole was prepared according to Lin et al. J. Org. Chem. 1979, 44, 4160. B] 1-(2-Hydroxyethyl)-3-(3-pyridinyl)-1H-1,2,4-triazole

Provenance & Evidence