Hydrazine → HCID 178515623, compound

HRID 889906Notes

Reaction equation

HRID 889906 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)=O.[NH2:15][NH2:16]>>[F:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[NH:16][N:15]=[C:3]([OH:2])[CH:4]=2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 9321HydrazineHCID 579425Methyl 4-fluorobenzoylacetate

Product 1

HCID 178515623HCID 178515623, compoundYield 84.4%

Procedure

5-(4-Fluoro-phenyl)-1H-pyrazol-3-ol (7.67 g, 84%) was prepared as a white solid from 3-(4-Fluoro-phenyl)-3-oxo-propionic acid methyl ester (10.0 g, 51.0 mmol) and hydrazine (4.76 mL, 153 mmol) by a procedure analogous to Example 22. C9H7FN2O: 1H NMR (d6-DMSO): δ 7.66 (dd, 2H, JCH—CF=11.7 Hz, JCH—CH=8.7 Hz), 7.21 (d, 2H, J=8.7 Hz), 5.83 (s, 1H) ppm.

Sources & evidence

ORD record
ord-8f645435c43a46a49cc4b651af13885c
Source dataset
uspto-grants-2006_02
Patent number
US06995171B2

Reaction notes

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