Hydrazine hydrate (1:1) → HCID 178488711, compound

HRID 889907Notes

Reaction equation

HRID 889907 reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1)=O)C.O.[NH2:18][NH2:19]>>[CH3:15][O:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]2[NH:19][N:18]=[C:4]([OH:3])[CH:5]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 76150Benzenepropanoic acid, 4-methoxy-beta-oxo-, ethyl ester

Product 1

HCID 178488711HCID 178488711, compoundYield 103.8%

Procedure

5-(4-Methoxy-phenyl)-1H-pyrazol-3-ol (30.8 g, 99%) was prepared as a white solid from 3-(4-methoxy-phenyl)-3-oxo-propionic acid ethyl ester (29.9 mL, 156 mmol) and hydrazine hydrate (14.6 mL, 468 mmol) by a procedure analogous to Example 22. C10H10N2O2: 1H NMR (D6-DMSO): δ 7.55 (d, J=8.8 Hz, 2H), 6.93 (d, J=8.8 Hz, 2H), 5.75 (s, 1H), 3.73 (s, 3H) ppm.

Sources & evidence

ORD record
ord-aecb4f9866d04b2c88d7b994ca7d7e5b
Source dataset
uspto-grants-2006_02
Patent number
US06995171B2

Reaction notes

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