反应详情

4-Cyano-2-methoxypyridine (1.7 g) was dissolved in MeOH (50 ml) and conc. HCl (4.96 ml) was added. Pd/C (10%) was added and H2 was added and let stand overnight. The solids were filtered through Celite® and the cake was washed with MeOH (˜250 ml). Concentration in vacuo produced an oil which was dissolved in MeOH (˜20 ml). Et2O (200 ml) was added and stirred for 1 h. The resulting precipitate was filtered and washed with Et2O to afford (2-methoxypyridin-4-yl)methylamine (hydrochloride salt) as an off-white solid.

1. additionH2 was added
2. filtrationThe solids were filtered through Celite®
3. washthe cake was washed with MeOH (˜250 ml)
4. concentrationConcentration in vacuo
5. customproduced an oil which
6. filtrationThe resulting precipitate was filtered
7. washwashed with Et2O