Ethylenediamine → N~1~-(Pyridin-2-yl)ethane-1,2-diamine

HRID 889987Notes

Reaction equation

[CH2:1]([NH2:4])[CH2:2][NH2:3].F[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1>>[N:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[NH:3][CH2:2][CH2:1][NH2:4]

Participants

Reactant 2

HCID 3301Ethylenediamine

HCID 97462-Fluoropyridine

Product 1

HCID 410428N~1~-(Pyridin-2-yl)ethane-1,2-diamine

Procedure

Ethylenediamine (6 g, 0.1 mol) and 2-fluoropyridine (10 g, 0.1 mol) were heated neat at 120° C. overnight. The reaction was cooled and the residue was used in next step without further purification.

Workup

temperatureThe reaction was cooled
customthe residue was used in next step without further purification

Sources & evidence

ORD record: ord-9e9488d12a94483e9a5dc31132f274b2
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06995162B2

Reaction notes

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