Hydrogen chloride-ethyl acetate → HCID 22248418, compound

HRID 890060Notes

Reaction equation

HRID 890060 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([S:14]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:25].[F:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[CH2:17][S:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)(=[O:15])=[O:16]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22248153HCID 22248153, compound

Product 1

HCID 22248418HCID 22248418, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

After dissolving 690 mg of 1-(tert-butoxycarbonyl)-4-(2-fluorobenzylsulfonyl)piperidine in 3 ml of ethyl acetate, 3 ml of 4N hydrogen chloride/ethyl acetate was added and the mixture was stirred at room temperature for 30 minutes. The precipitate was filtered out to obtain the title compound (517 mg, 91% yield).

Workup

  1. additionwas added
  2. filtrationThe precipitate was filtered out

Sources & evidence

ORD record
ord-5229aa20f4e948e6bc95154615f0fc1f
Source dataset
uspto-grants-2006_02
Patent number
US06995144B2

Reaction notes

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