Hydrogen chloride-ethyl acetate → 4-Cyano-4-(2-methylphenoxymethyl)piperidine hydrochloride

HRID 890088Notes

Reaction equation

HRID 890088 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:23]#[N:24])([CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25].C(OCC)(=O)C>>[ClH:25].[C:23]([C:11]1([CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)#[N:24]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 222481081-(tert-Butoxycarbonyl)-4-cyano-4-(2-methylphenoxymethyl)piperidine

Product 1

HCID 222482184-Cyano-4-(2-methylphenoxymethyl)piperidine hydrochloride

Procedure

After adding 10 ml of 4N hydrogen chloride/ethyl acetate to 273 mg of 1-(tert-butoxycarbonyl)-4-cyano-4-(2-methylphenoxymethyl)piperidine, the mixture was stirred for 6 hours at room temperature. The solvent was distilled off under reduced pressure to obtain 336 mg of 4-cyano-4-(2-methylphenoxymethyl)piperidine hydrochloride.

Workup

  1. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-c2dc2ec185664b2ca2152f471e5794f2
Source dataset
uspto-grants-2006_02
Patent number
US06995144B2

Reaction notes

Loading…