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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 890088Generated: October 31, 2026

Hydrogen chloride-ethyl acetate → 4-Cyano-4-(2-methylphenoxymethyl)piperidine hydrochloride

https://huagongshe.com/reaction/890088

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrogen chloride-ethyl acetateHCID 21866389—
Reactant1-(tert-Butoxycarbonyl)-4-cyano-4-(2-methylphenoxymethyl)piperidineHCID 22248108—
Product4-Cyano-4-(2-methylphenoxymethyl)piperidine hydrochlorideHCID 22248218—

Reaction Steps

After adding 10 ml of 4N hydrogen chloride/ethyl acetate to 273 mg of 1-(tert-butoxycarbonyl)-4-cyano-4-(2-methylphenoxymethyl)piperidine, the mixture was stirred for 6 hours at room temperature. The solvent was distilled off under reduced pressure to obtain 336 mg of 4-cyano-4-(2-methylphenoxymethyl)piperidine hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06995144B2
Source datasetuspto-grants-2006_02
ORD IDord-c2dc2ec185664b2ca2152f471e5794f2
Source noteuspto-grants-2006_02