反应详情

387 mg (2.51 mmol) of 2-cyanoethyl 3-aminocrotonate, 547 mg (2.49 mmol) of (3-(pyridine-3-yl)-2-propene-1-yl) acetoacetate, and 0.285 ml (2.51 mmol) of 3-chlorobenzaldehyde were heated at 80° C. under stirring in 20 ml of 2-propanol overnight. 2-Propanol was evaporated under reduced pressure, and the residue was purified by the silica gel chromatography (chloroform/methanol=100:1) to obtain the title compound.

1. custom2-Propanol was evaporated under reduced pressure
2. customthe residue was purified by the silica gel chromatography (chloroform/methanol=100:1)