反应详情

493 mg (4.0 mmol) of (2-cyanoethyl) propiolate, 745 ml (4.0 mmol) of (3-phenyl-2-propene-1-yl) propiolate, 0.453 ml (4.0 mmol) of 3-chlorobenzaldehyde and 617 mg (8.0 mmol) of ammonium acetate were heated at 60° C. under stirring in 8 ml of acetic acid for 12 hours. Acetic acid was evaporated under reduced pressure, and the residue was purified by the silica gel chromatography (hexane/ethyl acetate=1/1) to obtain the title compound.

1. customAcetic acid was evaporated under reduced pressure
2. customthe residue was purified by the silica gel chromatography (hexane/ethyl acetate=1/1)