HCID 22249928, compound → HCID 22249867, compound

HRID 890225Notes

Reaction equation

HRID 890225 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:12]3[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[CH:14][C:13]=3[CH3:20])[N:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:21])[C:3]=1[CH2:22][CH2:23]Cl>NC(CC)CC>[CH2:7]([CH:6]([N:5]1[C:2]2[C:11]3[CH:10]=[CH:9][N:8]=[C:7]([C:12]4[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[CH:14][C:13]=4[CH3:20])[C:6]=3[N:5]=[C:4]([CH3:21])[C:3]=2[CH2:22][CH2:23]1)[CH2:11][CH3:10])[CH3:12]

Participants

3

Reactant 1

HCID 22249928HCID 22249928, compound

Product 1

HCID 22249867HCID 22249867, compoundYield 198.9%

Reagents, catalysts & solvents 1

HCID 120193-PentanamineSolvent

Procedure

A solution of 4-chloro-3-(2-chloroethyl)-8-mesityl-2-methyl[1,7]naphthyridine (100 mg, 0.28 mmol) in 3-aminopentane (5.0 mL) was stirred at 200° C. for six hours in a sealed tube. After overnight, the residue was purified by silica gel column chromatography (30-50% ethyl acetate/hexane), to give the title compound (104 mg) as pale brown crystals.

Workup

  1. customthe residue was purified by silica gel column chromatography (30-50% ethyl acetate/hexane)

Sources & evidence

ORD record
ord-9dbbe7332b6d47c9aa5ed43decb21b1b
Source dataset
uspto-grants-2006_02
Patent number
US06995163B2

Reaction notes

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