Acrylonitrile → HCID 22250584, compound

HRID 890247Notes

Reaction equation

HRID 890247 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8]([CH3:11])=[CH:7]2.[C:12](#[N:15])[CH:13]=[CH2:14]>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:14][CH2:13][C:12]#[N:15])[C:8]([CH3:11])=[CH:7]2

Participants

4

Reactant 2

HCID 7855AcrylonitrileHCID 118160627-chloro-2-methyl-1H-indole

Product 1

HCID 22250584HCID 22250584, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
60 °C

Procedure

20 g of 7-chloro-2-methyl-1H-indole are mixed in 100 ml of dioxane with 3 g of triton B, 3 g of acrylonitrile are slowly added, 250 ml of dioxane are added again and then the mixture is heated at 60° C. for 2 hours. The medium is evaporated and then the residue is taken up in AcOEt. The precipitate formed being removed, the product obtained is used as is in the following stage.

Workup

  1. additionare slowly added
  2. customThe medium is evaporated
  3. customThe precipitate formed
  4. custombeing removed
  5. customthe product obtained

Sources & evidence

ORD record
ord-ba29b17d0fe24ef58b35fa9cc419cc88
Source dataset
uspto-grants-2006_02
Patent number
US06995184B2

Reaction notes

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