HCID 69596698, compound → HCID 69596721, compound

HRID 890274Notes

Reaction equation

HRID 890274 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[N:12]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[C@@H:11]([CH2:23][CH2:24][C:25](N)=[O:26])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]2[N:12]([S:13]([C:16]3[CH:17]=[CH:18][C:19]([CH3:22])=[CH:20][CH:21]=3)(=[O:15])=[O:14])[C@H:11]([CH2:23][CH2:24][CH2:25][OH:26])[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 69596698HCID 69596698, compound

Product 1

HCID 69596721HCID 69596721, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound, white solid, m.p. 96° C., [α]D20=−97.1° (c=1.0723 in chloroform) and MS: m/e=378.2 (M+H+)] was prepared in accordance with the general method of example 44 from (2S,5R)-3-[5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionic acid methyl ester [see example 59: colorless oil, [α]D20=−96.4° (c=1.0992 in chloroform) and MS: m/e=406.1 (M+H+)].

Sources & evidence

ORD record
ord-843ff4e3af794b8d9fee9fcea6777e34
Source dataset
uspto-grants-2006_02
Patent number
US06995182B2

Reaction notes

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