4-Toluenesulfonyl chloride → HCID 614168, compound

HRID 890280Notes

Reaction equation

HRID 890280 reaction equation
[CH3:1][O:2][C:3](=[O:9])[CH:4]1[CH2:8][CH2:7][CH2:6][NH:5]1.[C:10]1([CH3:20])[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1>>[CH3:1][O:2][C:3]([CH:4]1[CH2:8][CH2:7][CH2:6][N:5]1[S:16]([C:13]1[CH:14]=[CH:15][C:10]([CH3:20])=[CH:11][CH:12]=1)(=[O:18])=[O:17])=[O:9]

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 94239Methyl DL-prolinate

Product 1

HCID 614168HCID 614168, compound

Procedure

Reaction of DL-proline methylester with toluene-4-sulfonyl chloride according to the general procedure of example 1d yielded (RS)-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester as a white solid, m.p.=93° C. and MS: m/e=283 (M+).

Sources & evidence

ORD record
ord-f1c909365fbd4b96a4298048f820a68e
Source dataset
uspto-grants-2006_02
Patent number
US06995182B2

Reaction notes

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