反应详情

温度

70 °C

To a solution of 2-ethylcyclohexanone (104.3 mmol) in water and ethanol, and sodium acetate (125.1 mmol) were added hydroxylamine hydrochloride (156.4 mmol), the reaction was heated at 70° C. overnight. The ethanol was removed under reduced pressure, and the reaction mixture was dissolved in water. The aqueous layer was extracted with ether, and the combined organic extracts were washed with brine, dried over sodium sulfate, and concentrated to give 2-ethyl-1-(hydroxyimino)cyclohexane (52%) as a thick oil.

1. customThe ethanol was removed under reduced pressure
2. dissolutionthe reaction mixture was dissolved in water
3. extractionThe aqueous layer was extracted with ether
4. washthe combined organic extracts were washed with brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated