反应详情

A mixture of 1-(hydroxyimino)-2-methoxycyclohexane (1.05 mmol) and Raney Nickel (0.5 g) in ethanol (30 mL) was hydrogenated (90 psi) at room temperature for 2 days. The mixture was filtered through a pad of Celite, washed with MeOH, and concentrated. The residue was dissolved in MeOH, treated with HCl (4 N in dioxane, 4 mmol), and concentrated to give 2-methoxycyclohexylamine hydrochloride.

1. customat room temperature
2. customfor 2 days
3. filtrationThe mixture was filtered through a pad of Celite
4. washwashed with MeOH
5. concentrationconcentrated
6. dissolutionThe residue was dissolved in MeOH
7. concentrationconcentrated