Thionyl Chloride → HCID 21935918, compound

HRID 890424Notes

Reaction equation

HRID 890424 reaction equation
[CH3:1][C:2]1[C:7]([CH2:8]O)=[CH:6][N:5]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)[N:3]=1.S(Cl)([Cl:22])=O>ClCCl>[Cl:22][CH2:8][C:7]1[C:2]([CH3:1])=[N:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[N:5][CH:6]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 22250825HCID 22250825, compound

Product 1

HCID 21935918HCID 21935918, compoundYield 101.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1.33 g (4.96 mmol) [4-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-methanol and 0.72 ml (9.92 mmol) thionylchloride in 30 ml dichloromethane was stirred for 1 h at RT. The reaction mixture was concentrated under reduced pressure to give 1.44 g of pure 5-chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c55fd492f4654c4b958839673aca5a8d
Source dataset
uspto-grants-2006_02
Patent number
US06995263B2

Reaction notes

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