Thionyl Chloride → HCID 21935918, compound

Participants

Reaction Steps

A solution of 1.33 g (4.96 mmol) [4-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-methanol and 0.72 ml (9.92 mmol) thionylchloride in 30 ml dichloromethane was stirred for 1 h at RT. The reaction mixture was concentrated under reduced pressure to give 1.44 g of pure 5-chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine.

Provenance & Evidence