反应详情

To a solution of 300 mg (0.94 mmol) 5-chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine and 206 mg (0.94 mmol) (5-hydroxy-indol-1-yl)-acetic acid ethyl ester (example 1 c]) in 3 ml DMF was added 375 mg (1.15 mmol) cesium carbonate. The reaction mixture was stirred for 3 h at RT and then partitioned between ether and water. The crude product was purified by chromatography over silica gel with AcOEt/heptane 1.2 to give 194 mg of pure {5-[4-Methyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester.

1. custompartitioned between ether and water
2. customThe crude product was purified by chromatography over silica gel with AcOEt/heptane 1.2