Lithium Hydroxide → HCID 11476237, compound

HRID 890442Notes

Reaction equation

C([O:3][C:4](=[O:34])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:16][C:17]3[C:18]([CH3:33])=[N:19][C:20]([C:23]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=4)=[CH:21][CH:22]=3)[CH:13]=2)[CH2:8][CH2:7]1)C.[Li+].[OH-]>>[CH3:33][C:18]1[C:17]([CH2:16][O:15][C:12]2[CH:13]=[C:14]3[C:9]([CH2:8][CH2:7][N:6]3[CH2:5][C:4]([OH:34])=[O:3])=[CH:10][CH:11]=2)=[CH:22][CH:21]=[C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]([F:31])([F:30])[F:32])=[CH:27][CH:28]=2)[N:19]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69642139{6-[2-Methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-2,3-dihydro-indol-1-yl}-acetic acid ethyl ester

Product 1

HCID 11476237HCID 11476237, compound

Procedure

In analogy to the procedure described in example 5 g], {6-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-2,3-dihydro-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain {6-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-2,3-dihydro-indol-1-yl}-acetic acid as colorless crystals.

Sources & evidence

ORD record: ord-7af403bb754a4a28810e97d8153e7cc9
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06995263B2

Reaction notes

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