Lithium Hydroxide → HCID 11385798, compound

HRID 890444Notes

Reaction equation

C([O:3][C:4](=[O:36])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:16][C:17]3[C:18]([CH:33]4[CH2:35][CH2:34]4)=[N:19][C:20]([C:23]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=4)=[N:21][CH:22]=3)[CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[CH:33]1([C:18]2[C:17]([CH2:16][O:15][C:12]3[CH:13]=[C:14]4[C:9]([CH:8]=[CH:7][N:6]4[CH2:5][C:4]([OH:36])=[O:3])=[CH:10][CH:11]=3)=[CH:22][N:21]=[C:20]([C:23]3[CH:24]=[CH:25][C:26]([C:29]([F:32])([F:30])[F:31])=[CH:27][CH:28]=3)[N:19]=2)[CH2:35][CH2:34]1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69642248HCID 69642248, compound

Product 1

HCID 11385798HCID 11385798, compound

Procedure

In analogy to the procedure described in example 5 g], {6-[4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain {6-[4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid as colorless crystals.

Sources & evidence

ORD record: ord-e991281267a24f0cafdd2fa35bd0c105
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06995263B2

Reaction notes

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