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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 890451Generated: October 30, 2026

Lithium Hydroxide → (5-{2-[2-Methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-indol-1-yl)-acetic acid

https://huagongshe.com/reaction/890451

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium HydroxideHCID 3939—
ReactantHCID 69642331HCID 69642331—
Product(5-{2-[2-Methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-indol-1-yl)-acetic acidHCID 22250824—

Reaction Steps

In analogy to the procedure described in example 5 g], (5-{2-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-indol-1-yl)-acetic acid tert-butyl ester was treated with LiOH to obtain (5-{2-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-indol-1-yl)-acetic acid as light brown solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06995263B2
Source datasetuspto-grants-2006_02
ORD IDord-b11bd144a3654034bd2ee14e554716eb
Source noteuspto-grants-2006_02