Lithium Hydroxide → (5-{2-[2-Methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-indol-1-yl)-acetic acid

HRID 890451Notes

Reaction equation

C([O:5][C:6](=[O:37])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH2:18][CH2:19][C:20]3[C:21]([CH3:36])=[N:22][C:23]([C:26]4[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=4)=[CH:24][CH:25]=3)=[CH:14][CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[CH3:36][C:21]1[C:20]([CH2:19][CH2:18][O:17][C:13]2[CH:12]=[C:11]3[C:16](=[CH:15][CH:14]=2)[N:8]([CH2:7][C:6]([OH:37])=[O:5])[CH:9]=[CH:10]3)=[CH:25][CH:24]=[C:23]([C:26]2[CH:27]=[CH:28][C:29]([C:32]([F:34])([F:33])[F:35])=[CH:30][CH:31]=2)[N:22]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69642331HCID 69642331, compound

Product 1

HCID 22250824(5-{2-[2-Methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-indol-1-yl)-acetic acid

Procedure

In analogy to the procedure described in example 5 g], (5-{2-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-indol-1-yl)-acetic acid tert-butyl ester was treated with LiOH to obtain (5-{2-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-indol-1-yl)-acetic acid as light brown solid.

Sources & evidence

ORD record: ord-b11bd144a3654034bd2ee14e554716eb
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06995263B2

Reaction notes

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