Lithium Hydroxide → HCID 11396586, compound

HRID 890455Notes

Reaction equation

C([O:5][C:6](=[O:36])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][C:19]3[CH:20]=[N:21][C:22]([C:25]4[CH:30]=[CH:29][C:28]([O:31][C:32]([F:35])([F:34])[F:33])=[CH:27][CH:26]=4)=[CH:23][CH:24]=3)[CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[F:35][C:32]([F:33])([F:34])[O:31][C:28]1[CH:29]=[CH:30][C:25]([C:22]2[N:21]=[CH:20][C:19]([CH2:18][O:17][C:14]3[CH:15]=[C:16]4[C:11]([CH:10]=[CH:9][N:8]4[CH2:7][C:6]([OH:36])=[O:5])=[CH:12][CH:13]=3)=[CH:24][CH:23]=2)=[CH:26][CH:27]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69641953HCID 69641953, compound

Product 1

HCID 11396586HCID 11396586, compound

Procedure

In analogy to the procedure described in example 5 g], {6-[6-(4-trifluoromethoxy-phenyl)-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester was treated with LiOH to obtain the title compound as yellow crystals.

Sources & evidence

ORD record: ord-7a69dda3ca234c3083f2728a0c4ac5b3
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06995263B2

Reaction notes

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