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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 890457Generated: October 30, 2026

Lithium Hydroxide → {6-[2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid

https://huagongshe.com/reaction/890457

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium HydroxideHCID 3939—
Reactant{6-[2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl esterHCID 69641595—
Product{6-[2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acidHCID 11339650—

Reaction Steps

In analogy to the procedure described in example 5 g], {6-[2-methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain the title compound as off-white crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06995263B2
Source datasetuspto-grants-2006_02
ORD IDord-dfd917147f6c478f8b47aa7470838f21
Source noteuspto-grants-2006_02