Lithium Hydroxide → {6-[2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid

HRID 890457Notes

Reaction equation

HRID 890457 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:16][C:17]3[C:18]([CH3:33])=[N:19][C:20]([C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=4)=[CH:21][CH:22]=3)[CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[CH3:33][C:18]1[C:17]([CH2:16][O:15][C:12]2[CH:13]=[C:14]3[C:9]([CH:8]=[CH:7][N:6]3[CH2:5][C:4]([OH:34])=[O:3])=[CH:10][CH:11]=2)=[CH:22][CH:21]=[C:20]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:31])([F:30])[F:32])[CH:24]=2)[N:19]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 69641595{6-[2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester

Product 1

HCID 11339650{6-[2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid

Procedure

In analogy to the procedure described in example 5 g], {6-[2-methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain the title compound as off-white crystals.

Sources & evidence

ORD record
ord-dfd917147f6c478f8b47aa7470838f21
Source dataset
uspto-grants-2006_02
Patent number
US06995263B2

Reaction notes

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