1-Butanaminium, N,N,N-tributyl-, fluoride, hydrate → ethyl (4-hydroxy-1H-indol-1-yl)acetate

HRID 890459Notes

Reaction equation

HRID 890459 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][N:6]1[C:14]2[C:9](=[C:10]([O:15][Si](C(C)(C)C)(C)C)[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:2].O.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][N:6]1[C:14]2[C:9](=[C:10]([OH:15])[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:2]

Participants

3

Reactant 2

HCID 162116731-Butanaminium, N,N,N-tributyl-, fluoride, hydrateHCID 68822793HCID 68822793, compound

Product 1

HCID 68822476ethyl (4-hydroxy-1H-indol-1-yl)acetate

Procedure

In analogy to the procedure described in example 6 b], [4-(tert-butyl-dimethyl-silanyloxy)-indol-1-yl]-acetic acid ethyl ester was treated with tetrabutylammonium fluoride hydrate to obtain (4-hydroxy-indol-1-yl)-acetic acid ethyl ester as yellow oil.

Sources & evidence

ORD record
ord-03ae51af8cf842be9be88ba4ed67756d
Source dataset
uspto-grants-2006_02
Patent number
US06995263B2

Reaction notes

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