Lithium Hydroxide → 1h-Indole-1-acetic acid,4-[2-[2-methyl-6-[4-(trifluoromethyl)phenyl]-3-pyridinyl]ethoxy]-

HRID 890461Notes

Reaction equation

HRID 890461 reaction equation
C([O:3][C:4](=[O:35])[CH2:5][N:6]1[C:14]2[C:9](=[C:10]([O:15][CH2:16][CH2:17][C:18]3[C:19]([CH3:34])=[N:20][C:21]([C:24]4[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=4)=[CH:22][CH:23]=3)[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[CH3:34][C:19]1[C:18]([CH2:17][CH2:16][O:15][C:10]2[CH:11]=[CH:12][CH:13]=[C:14]3[C:9]=2[CH:8]=[CH:7][N:6]3[CH2:5][C:4]([OH:35])=[O:3])=[CH:23][CH:22]=[C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]([F:32])([F:31])[F:33])=[CH:28][CH:29]=2)[N:20]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 696377261h-Indole-1-acetic acid,4-[2-[2-methyl-6-[4-(trifluoromethyl)phenyl]-3-pyridinyl]ethoxy]-,ethyl ester

Product 1

HCID 114538181h-Indole-1-acetic acid,4-[2-[2-methyl-6-[4-(trifluoromethyl)phenyl]-3-pyridinyl]ethoxy]-

Procedure

In analogy to the procedure described in example 5 g], (4-{2-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-indol-1-yl)-acetic acid ethyl ester was treated with LiOH to obtain the title compound as white solid.

Sources & evidence

ORD record
ord-40e9bd05312a4258b076ab1593616cce
Source dataset
uspto-grants-2006_02
Patent number
US06995263B2

Reaction notes

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