Lithium Hydroxide → {6-[2-Cyclopropylmethyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid

HRID 890491Notes

Reaction equation

C([O:3][C:4](=[O:42])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:16][C:17]3[C:18]([CH2:38][CH:39]4[CH2:41][CH2:40]4)=[N:19][C:20]([C:27]4[CH:32]=[CH:31][C:30]([O:33][C:34]([F:37])([F:36])[F:35])=[CH:29][CH:28]=4)=[CH:21][C:22]=3[C:23]([F:26])([F:25])[F:24])[CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[CH:39]1([CH2:38][C:18]2[C:17]([CH2:16][O:15][C:12]3[CH:13]=[C:14]4[C:9]([CH:8]=[CH:7][N:6]4[CH2:5][C:4]([OH:42])=[O:3])=[CH:10][CH:11]=3)=[C:22]([C:23]([F:24])([F:25])[F:26])[CH:21]=[C:20]([C:27]3[CH:28]=[CH:29][C:30]([O:33][C:34]([F:37])([F:36])[F:35])=[CH:31][CH:32]=3)[N:19]=2)[CH2:41][CH2:40]1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 86597786{6-[2-Cyclopropylmethyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester

Product 1

HCID 11249981{6-[2-Cyclopropylmethyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid

Procedure

In analogy to the procedure described in example 5 g], {6-[2-cyclopropylmethyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain the title compound as brown solid.

Sources & evidence

ORD record: ord-c2a55454da204175921ed2dd499b9bb7
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06995263B2

Reaction notes

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