Methanol → [4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-acetic acid methyl ester

HRID 890493Notes

Reaction equation

HRID 890493 reaction equation
[CH:1]1([C:4]2[C:9]([CH2:10][C:11]([OH:13])=[O:12])=[CH:8][N:7]=[C:6]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=3)[N:5]=2)[CH2:3][CH2:2]1.[CH3:24]O>>[CH3:24][O:12][C:11](=[O:13])[CH2:10][C:9]1[C:4]([CH:1]2[CH2:3][CH2:2]2)=[N:5][C:6]([C:14]2[CH:15]=[CH:16][C:17]([C:20]([F:22])([F:23])[F:21])=[CH:18][CH:19]=2)=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 21935630[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-acetic acid

Product 1

HCID 69036962[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-acetic acid methyl ester

Procedure

In analogy to the procedure described in example 8 d], [4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-acetic acid was esterified with methanol to give the title compound as yellow solid.

Workup

  1. customdescribed in example 8 d

Sources & evidence

ORD record
ord-de7ca925457543c4921437f2359d96a0
Source dataset
uspto-grants-2006_02
Patent number
US06995263B2

Reaction notes

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