Diisobutylaluminum hydride → 2-[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-ethanol

HRID 890494Notes

Reaction equation

C[O:2][C:3](=O)[CH2:4][C:5]1[C:6]([CH:21]2[CH2:23][CH2:22]2)=[N:7][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)=[N:9][CH:10]=1.CC(C[AlH]CC(C)C)C>>[CH:21]1([C:6]2[C:5]([CH2:4][CH2:3][OH:2])=[CH:10][N:9]=[C:8]([C:11]3[CH:12]=[CH:13][C:14]([C:17]([F:19])([F:20])[F:18])=[CH:15][CH:16]=3)[N:7]=2)[CH2:23][CH2:22]1

Participants

Reactant 2

HCID 14487Diisobutylaluminum hydride

HCID 69036962[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-acetic acid methyl ester

Product 1

HCID 222508192-[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-ethanol

Procedure

In analogy to the procedure described in example 1 f], [4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-acetic acid methyl ester was reacted with DIBAL-H to give the title compound as yellow solid.

Sources & evidence

ORD record: ord-f065857e869b4aadbce0b9194a8d5ca5
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06995263B2

Reaction notes

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