Lithium Hydroxide → (6-{2-[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-ethoxy}-indol-1-yl)-acetic acid

HRID 890496Notes

Reaction equation

C([O:3][C:4](=[O:37])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:16][CH2:17][C:18]3[C:19]([CH:34]4[CH2:36][CH2:35]4)=[N:20][C:21]([C:24]4[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=4)=[N:22][CH:23]=3)[CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[CH:34]1([C:19]2[C:18]([CH2:17][CH2:16][O:15][C:12]3[CH:13]=[C:14]4[C:9]([CH:8]=[CH:7][N:6]4[CH2:5][C:4]([OH:37])=[O:3])=[CH:10][CH:11]=3)=[CH:23][N:22]=[C:21]([C:24]3[CH:25]=[CH:26][C:27]([C:30]([F:33])([F:31])[F:32])=[CH:28][CH:29]=3)[N:20]=2)[CH2:36][CH2:35]1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69641848(6-{2-[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-ethoxy}-indol-1-yl)-acetic acid ethyl ester

Product 1

HCID 11213813(6-{2-[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-ethoxy}-indol-1-yl)-acetic acid

Procedure

In analogy to the procedure described in example 5 g], (6-{2-[4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-ethoxy}-indol-1-yl)-acetic acid ethyl ester was treated with LiOH to obtain the title compound as yellow solid.

Sources & evidence

ORD record: ord-3461e51dcaf74b30a9e37271ff629ebc
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06995263B2

Reaction notes

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