Lithium Hydroxide → HCID 11295175, compound

HRID 890499Notes

Reaction equation

C([O:3][C:4](=[O:38])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:16][C:17]3[C:18]([C:34]([F:37])([F:36])[F:35])=[N:19][C:20]([C:23]4[CH:28]=[CH:27][C:26]([O:29][C:30]([F:33])([F:32])[F:31])=[CH:25][CH:24]=4)=[CH:21][CH:22]=3)[CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[F:33][C:30]([F:31])([F:32])[O:29][C:26]1[CH:27]=[CH:28][C:23]([C:20]2[N:19]=[C:18]([C:34]([F:35])([F:36])[F:37])[C:17]([CH2:16][O:15][C:12]3[CH:13]=[C:14]4[C:9]([CH:8]=[CH:7][N:6]4[CH2:5][C:4]([OH:38])=[O:3])=[CH:10][CH:11]=3)=[CH:22][CH:21]=2)=[CH:24][CH:25]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 86597788HCID 86597788, compound

Product 1

HCID 11295175HCID 11295175, compound

Procedure

In analogy to the procedure described in example 5 g], {6-[6-(4-trifluoromethoxy-phenyl)-2-trifluoromethyl-pyridin-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain the title compound as colorless solid.

Sources & evidence

ORD record: ord-972d9134df8d4f529326666b342d10d4
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06995263B2

Reaction notes

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