(6-Chloropyridin-2-yl)methanol → 4-[2-(6-Chloro-pyridin-2-ylmethoxy)-pyrimidin-4-yl]-piperazine-1-carboxylic Acid Tert-Butyl Ester

HRID 890573Notes

Reaction equation

HRID 890573 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][CH:3]=1.[C:10]([O:14][C:15]([N:17]1[CH2:22][CH2:21][N:20]([C:23]2[CH:28]=[CH:27][N:26]=[C:25](Cl)[N:24]=2)[CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:12])[CH3:11]>>[C:10]([O:14][C:15]([N:17]1[CH2:22][CH2:21][N:20]([C:23]2[CH:28]=[CH:27][N:26]=[C:25]([O:9][CH2:8][C:6]3[CH:5]=[CH:4][CH:3]=[C:2]([Cl:1])[N:7]=3)[N:24]=2)[CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:11])[CH3:12]

Participants

3

Reactant 2

HCID 182139(6-Chloropyridin-2-yl)methanolHCID 11197306Tert-butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

Product 1

HCID 865883644-[2-(6-Chloro-pyridin-2-ylmethoxy)-pyrimidin-4-yl]-piperazine-1-carboxylic Acid Tert-Butyl Ester

Procedure

The title compound (I-5b) was prepared from (6-chloro-pyridin-2-yl)-methanol (I-5a) and 4-(2-chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester (I-1 a) according to a procedure analogous to that described in Example 1.

Sources & evidence

ORD record
ord-8a2202714c4245c495c53c783c56b026
Source dataset
uspto-grants-2006_02
Patent number
US06995159B2

Reaction notes

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