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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 890574Generated: October 29, 2026

Trifluoroacetic acid → 2-(6-Chloro-pyrdin-2-ylmethoxy)-4-piperazin-1-yl-pyrimidine, hydrochloride

https://huagongshe.com/reaction/890574

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant4-[2-(6-Chloro-pyridin-2-ylmethoxy)-pyrimidin-4-yl]-piperazine-1-carboxylic Acid Tert-Butyl EsterHCID 86588364—
Product2-(6-Chloro-pyrdin-2-ylmethoxy)-4-piperazin-1-yl-pyrimidine, hydrochlorideHCID 131725273—

Reaction Steps

The title compound (5-A) was prepared from 4-[2-(6-chloro-pyridin-2-ylmethoxy)-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester (I-5b) and TFA according to a procedure analogous to that described in Example 3.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06995159B2
Source datasetuspto-grants-2006_02
ORD IDord-6c46cd81567d4f41ad31363ea86a5faa
Source noteuspto-grants-2006_02