Trifluoroacetic acid → 2-(6-Chloro-pyrdin-2-ylmethoxy)-4-piperazin-1-yl-pyrimidine, hydrochloride

HRID 890574Notes

Reaction equation

HRID 890574 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([O:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[N:23]=3)[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[ClH:28].[Cl:28][C:24]1[N:23]=[C:22]([CH2:21][O:20][C:16]2[N:15]=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:19]=[CH:18][N:17]=2)[CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 865883644-[2-(6-Chloro-pyridin-2-ylmethoxy)-pyrimidin-4-yl]-piperazine-1-carboxylic Acid Tert-Butyl Ester

Product 1

HCID 1317252732-(6-Chloro-pyrdin-2-ylmethoxy)-4-piperazin-1-yl-pyrimidine, hydrochloride

Procedure

The title compound (5-A) was prepared from 4-[2-(6-chloro-pyridin-2-ylmethoxy)-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester (I-5b) and TFA according to a procedure analogous to that described in Example 3.

Sources & evidence

ORD record
ord-6c46cd81567d4f41ad31363ea86a5faa
Source dataset
uspto-grants-2006_02
Patent number
US06995159B2

Reaction notes

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