Chlorotrimethylsilane → HCID 9956431, compound

HRID 890614Notes

Reaction equation

HRID 890614 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][NH:12][CH:13]2[CH2:18][CH2:17][C:16]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)([N:19]([CH3:21])[CH3:20])[CH2:15][CH2:14]2)=[CH:2]1.[Cl:28][Si](C)(C)C>CC(=O)CC>[ClH:28].[ClH:28].[ClH:28].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][NH:12][CH:13]2[CH2:18][CH2:17][C:16]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)([N:19]([CH3:20])[CH3:21])[CH2:15][CH2:14]2)=[CH:2]1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 9956432HCID 9956432, compound

Product 1

HCID 9956431HCID 9956431, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

As described for example 1, 171 mg of the polar diastereoisomer of N′-[2-(1H-indol-3-yl)ethyl]-N,N-dimethyl-1-pyridin-2-yl cyclohexane-1,4-diamine were also obtained, dissolved in 2-butanone (20 ml) and converted into the corresponding trihydrochloride with chlorotrimethyl silane (0.297 ml) (171 mg beige solid, mp 225–230° C.).

Workup

  1. customwere also obtained

Sources & evidence

ORD record
ord-c3f9190f31af46c9934bcfeca03fffa0
Source dataset
uspto-grants-2006_02
Patent number
US06998409B2

Reaction notes

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