Hydrochloric Acid → HCID 21866815, compound

HRID 890666Notes

Reaction equation

HRID 890666 reaction equation
C([S:4][CH2:5][CH:6]([CH2:24][S:25]C(=O)C)[CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[N:12]=[C:13]([C:17]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=2)[O:14][C:15]=1[CH3:16])(=O)C.[OH-].[Na+].Cl>CO>[SH:4][CH2:5][CH:6]([CH2:24][SH:25])[CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[N:12]=[C:13]([C:17]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=2)[O:14][C:15]=1[CH3:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21866652HCID 21866652, compound

Product 1

HCID 21866815HCID 21866815, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 8 ml of a solution of 830 mg of 4-[5,5-bis(acetylthiomethyl)pentyl]-5-methyl-2-(p-tolyl)oxazole in methanol, 8 ml of aqueous 1 N sodium hydroxide solution was added, and heated to reflux for 1 hour. The reaction solution was acidified with 1 N hydrochloric acid, extracted with dichloromethane and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to provide 635 mg of the objective compound as pale yellow oil.

Workup

  1. temperatureheated
  2. temperatureto reflux for 1 hour
  3. extractionextracted with dichloromethane
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-b6bcecfe4b3747f68b9ff4c04d2dd003
Source dataset
uspto-grants-2006_02
Patent number
US06998412B2

Reaction notes

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