反应详情

10 g (54.2 mmol) of 2-(4-methylphenyl)ethanamidine hydrochloride (Example 3A) are taken up in 100 ml of ethanol and treated with 3.25 g (65.0 mmol) of hydrazine hydrate. The mixture is stirred for 45 min, then the compound of Example 6A is added. It is then stirred for 4 h at 80° C. (bath) and overnight at room temperature. The substance is purified by flash chromatography, preliminary fractions first being separated off using ethyl acetate. The product is eluted with dichloromethane/methanol 30/1.

1. stirringIt is then stirred for 4 h at 80° C. (bath) and overnight at room temperature
2. customThe substance is purified by flash chromatography, preliminary fractions
3. customfirst being separated off
4. washThe product is eluted with dichloromethane/methanol 30/1