Phosphorus oxychloride → 7-(1-acetylhexyl)-5-methyl-2-(4-methylbenzyl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one
Reaction equation
[C:1]([CH:4]([CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[C:5]([NH:7][CH:8]([C:10]1[C:11](=[O:24])[NH:12][C:13]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=2)=[N:14][N:15]=1)[CH3:9])=O)(=[O:3])[CH3:2].P(Cl)(Cl)(Cl)=O>>[C:1]([CH:4]([C:5]1[N:15]2[C:10]([C:11](=[O:24])[NH:12][C:13]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=3)=[N:14]2)=[C:8]([CH3:9])[N:7]=1)[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])(=[O:3])[CH3:2]Participants
3
Procedure
Analogously to Example 1, 520 mg (1.30 mmol) of 2-acetyl-N-{1-[3-(4-methylbenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}heptanamide (Example 24A) and 1.99 g (13.0 mmol) of phosphorus oxychloride are reacted to give 7-(1-acetylhexyl)-5-methyl-2-(4-methylbenzyl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one.
Sources & evidence
- ORD record
- ord-84220d3603fc4959a7e463ae2b8bca1e
- Source dataset
- uspto-grants-2006_02
- Patent number
- US06998402B2
Reaction notes
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