Phosphorus oxychloride → HCID 135449956, compound

HRID 890716Notes

Reaction equation

HRID 890716 reaction equation
[C:1]([CH:4]([CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[C:5]([NH:7][CH:8]([C:10]1[C:11](=[O:25])[NH:12][C:13]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=2)=[N:14][N:15]=1)[CH3:9])=O)(=[O:3])[CH3:2].P(Cl)(Cl)(Cl)=O>>[C:1]([CH:4]([C:5]1[N:15]2[C:10]([C:11](=[O:25])[NH:12][C:13]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=3)=[N:14]2)=[C:8]([CH3:9])[N:7]=1)[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 1356979172-acetyl-N-{1-[3-(4-methoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}octanamide

Product 1

HCID 135449956HCID 135449956, compound

Procedure

Analogously to Example 1, 710 mg (1.65 mmol) of 2-acetyl-N-{1-[3-(4-methoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}octanamide (Example 27A) and 1.23 g (8.00 mmol) of phosphorus oxychloride are reacted to give 7-(1-acetylheptyl)-2-(4-methoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one.

Sources & evidence

ORD record
ord-2d0b5d0240ef409985ccae1e138db154
Source dataset
uspto-grants-2006_02
Patent number
US06998402B2

Reaction notes

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