Hydrochloric Acid → HCID 69544410, compound

HRID 890819Notes

Reaction equation

HRID 890819 reaction equation
[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH2:11][CH2:12][NH:13]C(OC(C)(C)C)=O)[CH:5]=1.[ClH:22]>CO>[ClH:22].[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH2:11][CH2:12][NH2:13])[CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54063952HCID 54063952, compound

Product 1

HCID 69544410HCID 69544410, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3-(3-tert-butoxycarbonylamino-propyl)-benzoic acid methyl ester (565 mg) in MeOH (25 mL) was cooled to 0° C. and the solution was saturated with HCl (g). The reaction was stirred at room temperature for 1.5 h and was concentrated in vacuo to provide the title amine (399 mg). MS 194 (M+1).

Workup

  1. concentrationwas concentrated in vacuo

Sources & evidence

ORD record
ord-6a314a6a0b7a4f569673e05064fbf92f
Source dataset
uspto-grants-2006_02
Patent number
US06998423B2

Reaction notes

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