反应详情

温度

0 °C

In a 250 ml round-bottomed flask equipped with a magnetic stirrer were taken a mixture of ornithine methyl ester dihydrochloride (5.0 g) and 2-nitrobenzaldehyde (7.5 g) in MDC (70 ml). The suspension was stirred at 0° C. for 15 mts. Triethylamine (4.64 g in 10 ml MDC) was added slowly. The reaction mixture was then allowed to stir at RT overnight. The reaction mixture was diluted with MDC, washed with water twice and dried over sodium sulfate. MDC was evaporated to give the crude product which was crystallized from methanol to give a white crystalline solid.

1. customIn a 250 ml round-bottomed flask equipped with a magnetic stirrer
2. stirringto stir at RT overnight
3. additionThe reaction mixture was diluted with MDC
4. washwashed with water twice
5. dry with materialdried over sodium sulfate
6. customMDC was evaporated