Triethylamine → 2-Chloro-4,5-diphenyloxazole

Participants

Reaction Steps

4,5-Diphenyloxazolone from Step 1 (30 g, 0.126 mol), triethylamine (12.8 g, 0.126 mol), and phosphorous oxychloride (96.6 g, 0.63 mol) were stirred at reflux for 4.0 hours. The mixture was concentrated in vacuo, dissolved in ether (250 mL), washed with 1N HCl, brine, and water, dried over MgSO4 and concentrated to a light yellow oil which was used in the next step without further purification or characterization.

Provenance & Evidence