反应详情

4,5-Diphenyloxazolone from Step 1 (30 g, 0.126 mol), triethylamine (12.8 g, 0.126 mol), and phosphorous oxychloride (96.6 g, 0.63 mol) were stirred at reflux for 4.0 hours. The mixture was concentrated in vacuo, dissolved in ether (250 mL), washed with 1N HCl, brine, and water, dried over MgSO4 and concentrated to a light yellow oil which was used in the next step without further purification or characterization.

1. temperatureat reflux for 4.0 hours
2. concentrationThe mixture was concentrated in vacuo
3. dissolutiondissolved in ether (250 mL)
4. washwashed with 1N HCl, brine, and water
5. dry with materialdried over MgSO4
6. concentrationconcentrated to a light yellow oil which
7. customwas used in the next step without further purification or characterization