N-(5-Benzyloxy-2-formylphenyl)-N-(2-hydroxypropyl)-formamide → HCID 22247174, compound

HRID 890896Notes

Reaction equation

HRID 890896 reaction equation
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=[O:14])=[C:11]([N:17]([CH2:20][CH:21]([OH:23])[CH3:22])C=O)[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=[O:14])=[C:11]([NH:17][CH2:20][CH:21]([OH:23])[CH3:22])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 22247178N-(5-Benzyloxy-2-formylphenyl)-N-(2-hydroxypropyl)-formamide

Product 1

HCID 22247174HCID 22247174, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Compound 3 is reacted with a base or an acid in the presence of water and an organic solvent, to yield (±)-4-benzyloxy-2-(2-hydroxypropyl)aminobenzaldehyde (6). Preferably, base is used and the preferred base is sodium hydroxide or potassium hydroxide and the preferred solvent is tetrahydrofuran and the temperature is 0 to 35° C., preferably 20 to 25° C. Preferably, an inert atmosphere, e.g., nitrogen or argon, is maintained.

Sources & evidence

ORD record
ord-40f214e94e6949ef9778e08dc93fc3b5
Source dataset
uspto-grants-2006_02
Patent number
US06998489B2

Reaction notes

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