N-(5-Benzyloxy-2-formylphenyl)-N-(2-hydroxypropyl)-formamide → HCID 22247174, compound

Participants

Reaction Steps

Compound 3 is reacted with a base or an acid in the presence of water and an organic solvent, to yield (±)-4-benzyloxy-2-(2-hydroxypropyl)aminobenzaldehyde (6). Preferably, base is used and the preferred base is sodium hydroxide or potassium hydroxide and the preferred solvent is tetrahydrofuran and the temperature is 0 to 35° C., preferably 20 to 25° C. Preferably, an inert atmosphere, e.g., nitrogen or argon, is maintained.

Provenance & Evidence