2-(Methylamino)ethanol → HCID 22244137, compound

HRID 890962Notes

Reaction equation

HRID 890962 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.[CH3:9][NH:10][CH2:11][CH2:12][OH:13]>C(O)C.O>[Cl:8][C:6]1[N:7]=[CH:2][N:3]=[C:4]([N:10]([CH3:9])[CH2:11][CH2:12][OH:13])[CH:5]=1

Participants

5

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 775312,4-Dichloropyrimidine

Product 1

HCID 22244137HCID 22244137, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 14.8 g (0.1 mmol) 2,4-dichloropyrimidine in 120 ml ethanol and 20 ml water, cooled to 0° C., 11.3 g (0.15 mol) 2-(N-methylamino)ethanol is added. The resulting mixture is stirred at room temperature for ½ h., then concentrated to dryness and finally partitioned between CH2Cl2 and a NaHCO3 saturated solution.

Workup

  1. concentrationconcentrated to dryness
  2. customfinally partitioned between CH2Cl2

Sources & evidence

ORD record
ord-70a63d92fb7a4610b97f042a7ecb205c
Source dataset
uspto-grants-2006_02
Patent number
US07001910B1

Reaction notes

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