HCID 22244137, compound → Ethanol, 2-(methyl-4-pyrimidinylamino)-

HRID 890963Notes

Reaction equation

HRID 890963 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]([CH3:12])[CH2:9][CH2:10][OH:11])[CH:3]=1>C(O)C.O.[Pd]>[CH3:12][N:8]([C:4]1[CH:3]=[CH:2][N:7]=[CH:6][N:5]=1)[CH2:9][CH2:10][OH:11]

Participants

5

Reactant 1

HCID 22244137HCID 22244137, compound

Product 1

HCID 23598948Ethanol, 2-(methyl-4-pyrimidinylamino)-

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To 9.4 g (50 mmol) 2-[(6-chloropyrimidin-4-yl)-methylamino)ethanol in 50 ml ethanol and 10 ml water, 1 g of a 10% Pd/C paste is added and the resulting mixture is subjected to hydrogenation at a pressure of 60 atmospheres and at room temperature for 8 h.

Sources & evidence

ORD record
ord-c0952f1c0c97433f9d0d5d03fe032bfe
Source dataset
uspto-grants-2006_02
Patent number
US07001910B1

Reaction notes

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